Endothelial Dysfunction and Inflammation

P 61: MicroRNA as a Therapeutic Tool to Prevent Blood Brain Barrier Dysfunction in Neuroinflammation

Endothelial cells present in brain are unique and differ from other peripheral tissues in a number of ways, which ensures specific brain endothelial barrier properties. Endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation. Various microRNAs (miRNA) have been discovered in different cellular components of the blood bran barrier (BBB). miRNAs a...

Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta

Objective: Diabetes is an important risk factor for cardiovascular events. The great percent of morbidity in patients with diabetes is due to endothelial dysfunction. The present study investigated the effects of hydroalcholic extract of Nigella sativa (N. sativa)  on contractile and dilatation response of isolated aorta in streptozotocin (STZ)-induced diabetic rat. Materials and Methods: Rats ...

The effect of omega- 3 polyunsaturated fatty acids on endothelial tight junction occludin expression in rat aorta during lipopolysaccharide-induced inflammation

Objective(s): Occludin is essential for proper assembly of tight junctions (TJs) which regulate paracellular endothelial permeability. Omega-3 polyunsaturated fatty acids (Ω-3 PUFA) protect endothelial barrier function against injury. Materials and Methods: We examined anti-inflammatory effect of Ω-3 PUFA intake (30 mg/kg/day for 10 days) on expression and location of occludin in the aorta of ...

Endothelial Progenitor Cell Dysfunction in Polycystic Ovary Syndrome: Implications for The Genesis of Cardiovascular Diseases

THE EFFECTS OF COMBINED EXERCISE WITH AND WITHOUT DIET ON PLASMA INFLAMMATORY BIOMARKERS AND ENDOTHELIAL DYSFUNCTION IN ELDERLY PATIENTS WITH TYPE 2 DIABETES

Background: Inflammation plays an important role in the incidence and development of metabolic disorders and exercises along with dietary restrictions for weight loss. It has beneficial effects on reducing inflammatory markers, especially in type 2 diabetes. The purpose of this study was to evaluate the effect of combined exercise (resistance-aerobic) with and without diet restriction on weight...

Age associated endothelial dysfunction: Role of oxidative stress, inflammation and Western Diet

Aging is a major risk factor in the development of cardiovascular diseases attributed to the development of vascular endothelial dysfunction. Reduced bioavailability of endothelialnitric oxide (NO) synthase (eNOS) and its product NO is considered the key mechanism mediating reduced endothelial function with aging. Vascular oxidative stress and inflammation increase with age and Western diets ri...